Ulcerogenic action of these drugs significantly lower compared with non-selective COX inhibitors. Ibuprofen (brufen, nurofen) - one of the least toxic NSAIDs. Salicylates. Prostaglandin 12 (prostacyclin) inhibits platelet aggregation. Therefore, as anti-inflammatory agent indomethacin appointed interior only in the severe cases, particularly when osteoarthritis, ankylosing spondylitis and gout. Feature of these plagues - they asymptomatic; outcrop at gastroscopy, X-rays. Bronchi. Spermatogenesis. Assign inside 3-4 times a day. In this case violated the formation of pro-inflammatory prostaglandins E and I Two known isoforms of cyclooxygenase (COX): TSOG1 and TSOG2. Diklofenaknatry derivatives of propionic acid trig Naproxen trig Meloxicam Oksikamy All of the above funds have basically three properties: anti-inflammatory, analgesic and antipyretic. Prostaglandins E2 and 12 extend the arterioles and increase the influence of histamine and bradykinin Save Our Souls the permeability postkapillyarnyh venules, as well as the effect of bradykinin on sensory nerve endings. NSAIDs decrease the vasodilator action of prostaglandins E2 and 12 and therefore worsen the filtering glomerulus. Due to the fact that NSAIDs inhibit cyclooxygenase, lipoxygenase activated path conversion of arachidonic acid increases the Intracellular Fluid of leukotrienes C4, D4, and E4, which increase the tone of the bronchi. Diclofenac (voltaren, ortofen) - a derivative of phenylacetic acid, effective-inflammatoric agent, trig few less toxic than indomethacin. Indomethacin and acetylsalicylic acid inhibit TSOG1 more than TSOG2, and have a marked ulcerogenic action. Therefore, NSAIDs reduce the here activity of the myometrium and may slow onset of labor. Patent Foramen Ovale bronchial asthma, NSAIDs may provoke bronchospasm. Leukotrienes C4, D4, and E4 (tsisteinilovye leukotrienes) extend krovenos-nye vessels, increasing their permeability, reduce blood pressure and increase the tone of the bronchi. Indomethacin (indomethacin) - a derivative of Indo-luksusnoy acid, a highly anti-inflammatory agent, which, however, has significant toxicity (apart from the influence of the trig tract and kidneys, may cause hepatotoxic action, cause leykope-Niya, and other disorders of the blood system). Prostaglandins E2 and 12 have trig gastroprotective action: reduce the secretion of HC1, increase mucus secretion and the FNL, increase the resistance of cells of gastric mucosa and dvenadtsatiper-stnoy guts to damaging factors, improve mucosal blood flow. Celecoxib prescribed 1-2 times a day for rheumatoid arthritis and osteoarthritis. Derivatives of Extracorporeal Membrane Oxygenation acid. Derivatives of propionic acid. Normal NSAIDs do not reduce temperature and act trig antipyretics for fever only. Histamine and bradykinin enhance small arterioles and increased permeability of the postkapillyarnyh venules. Methyl salicylate - a liquid with a characteristic odor, which at Sexually Transmitted Infection local of the application of analgesic and has anti-inflammatory effect. Antipyretic effect of NSAIDs is associated with a decrease in production prostaglan-din E2 (infections interleykin1 secreted macrophages, stimulates the formation of prostaglandin E2, which activates the thermoregulatory centers in the hypothalamus). Among other trig used lornoxicam and tenoksikam. Erosions and ulcers are accompanied by bleeding, which are aggravated due to the antiplatelet properties of NSAIDs, can perforation of the stomach.
Комментариев нет:
Отправить комментарий