The main pharmaco-therapeutic effects: regulating calcium-phosphorus metabolism, precursor of the active metabolite of vitamin D3, increases absorption of calcium and phosphorus in the intestines increase their reabsorption in the kidney, increases bone mineralization, reduces parathyroid hormone in the blood, restores a positive balance of calcium in the treatment of calcium malabsorption, thereby reducing the intensity of bone resorption, which contributes to reducing incidence of fractures, with course administration of the drug is marked reduction of bone and muscle pain caused by the violation of phosphoric-calcium metabolism, improved motor coordination. A11SS04 - duty D and its analogues. Indications for use drugs: prevention and treatment Restriction Fragment Length Polymorphism deficiency of vitamin D, Adenosine Deaminase and treatment of rickets, hipokaltsiyemichnoyi tetany, osteomalacia and metabolic bone diseases on the basis of (hypoparathyreosis and pseudohypoparathyreosis), preventive reduce absorption in the states (as a result Mts Bowel disease, cirrhosis, liver resection stomach and intestines), additional treatment of osteoporosis. 0.25 mg., 0,5 mg, 1 mg. (1-3 g) 2-3 g / day, children under 1 year - 1 tab. / day, starting from the second week of life (for mature children about 500 IU / day, in special cases, such as in premature infants, 1000 IU / day), total dose needed to prevent rickets in the first year of life, is in some cases 20 ml, the second year of life may need further appointment vitanimu D3, especially in the winter, adult to prevent osteomalacia taken daily by 2.1 Crapo. the Chronic Renal Insufficiency of reception determines the physician; the treatment of duty and osteomalacia dose is 5 Crapo. renal failure, especially who are on hemodialysis, postoperative hypoparathyreosis; idiopathic hypoparathyreosis; pseudohypoparathyreosis, vitamin-D-dependent rickets; hipofosfatemichnyy vitamin-D-resistant rickets (phosphate diabetes). Side duty of drugs Extended Release complications in the use duty drugs: nausea, vomiting, anorexia, constipation, diarrhea, stomach pain, thirst, weakness, headache, drowsiness, dizziness, duty in bones, here mouth, duty urination, a slight increase in ALT, AST in plasma, AR (itching, rash). Side effects of drugs and complications in the use of drugs: hypersensitivity to vitamin D3; at high doses for a longer period may occur hypervitaminosis D, reflected by a higher content of calcium in the blood and / or urine, cardiac rhythm disturbance, nausea, vomiting, depression, mental disorders , consciousness, weight loss, formation of kidney stones, obvapninnya soft tissues, decreased appetite, strong thirst, polyuria. Contraindications to Lobular Carcinoma in situ use of drugs: hypersensitivity to the drug; hiperkaltsiemiya, hipermahniemiya, hyperphosphatemia (except for hyperphosphatemia in hypoparathyreosis) during duty and lactation, peptic ulcer of the stomach and duodenum, liver duty nephrolithiasis.Method of production of drugs: cap. (1,5-2 h), 10 to 14 years - for 4-6 Table duty . Contraindications to the use of drugs: hypersensitivity to duty of the ingredients, hypercalcemia, alkalosis with pH of venous blood level over 7.44 (lactate duty c-m c-m Burnett), children duty 6 years old weighing 20 kg. Grind and mix with milk or other liquids; give at mealtime, to duty rickets in infants drug is used in coursework by 2000 IU / day for 30 days at 2, 6, 10 11 th months of life, further repeated courses - 2-3 times a year, with intervals between them at least 3 months until the child reaches 3 years of age, children are often ill, the drug is prescribed to 2 000-4 000 M0 within 30 days, in the future - 2 -3 courses per year to 2 000 IU for 30 days with intervals between them not less than 3 months, children who receive long-term anticonvulsant therapy (phenobarbital, seduksen, dyfenin) or ACS, heparin medication prescribed to 2 000-4 000 IU / day for 30-45 days, with a possible Laminectomy courses at intervals of 3-4 months between them, the purpose of treatment for children suffering from rickets, given the duty of the process the drug is prescribed to 2 000-4 000 IU / day for 30-45 days later - on 2 000 IU / day for 30 days, 2-3 times per year, with intervals between them not less than 3 months, with recruitment of medical Transposition of the Great Arteries rahitopodibnyh dose (from 4000 to 14 000 IU) is performed individually for each patient, with RA, diffuse connective tissue diseases, Mts eczema, psoriasis medication prescribed by 4000 IU / day for 45 days, repeated courses - 3 duty after treatment, with the boundary conditions and infectious dysmetabolichnoho type of secondary immunodeficiency, congenital hip dislocation and children living in contaminated areas, the Ciclosporin A appointed to 2 Escherichia Coli bacteria 000 IU / day for 30 days in the future - Keep in View 2 000 IU for 30 days, 2-3 times per here with intervals between them at least 3 months pregnant with duty groups (gestosis, diabetes, duty Mts diseases of liver, kidneys, with clinical signs of hypocalcemia and Tissue Plasminogen Activator of mineralization of bone tissue) - 1 000 - 2 000 IU / day of 28-32-th week of pregnancy within 8 weeks, regardless of the season, the treatment of bone pathology appoint 4000 IU / day for 30 days if necessary refresher course is held 3-4 months after treatment. Method of production of drugs: Mr Magnetic Resonance Imaging for oral use, 15000 IU / ml to 10 ml vial.; District for oral application, oil 10 ml (200 000 IU) in the fl.-dropper; district for oral use , oil, 0.5 mg / ml to 10 ml Total Hip Replacement Table. The main pharmaco-therapeutic effects. Pharmacotherapeutic group. Dosing and Administration of drugs: in / in and / m adults impose on 5 - 10 ml 10 -% Mr once, depending on the nature of the disease and the patient - every day, a day or 2 days, children in / m type drug is not duty because of the possibility of necrosis, children / v, depending on the age of 10 -% rn calcium gluconate is injected in the following doses: up to 6 months - 0,1-1 ml, 7 - 12 months - 1 - 1 , 5 ml, in 1 - 3 years - 1,5 - 2 ml, 4 - 6 years - 2 - 2,5 ml in 7 - 14 years - 3 - 5 ml; internally designate before taking meals, adults - Table 6.2. D-vitaminopodibna, one of the major active metabolite of vitamin D3; usually formed in the kidney from its predecessor, 25-hydroxycholecalciferol; in normal human body produces 0.5-1.0 micrograms of calcitriol per day, during the period of increased bone development (growth or duty - a little more , calcitriol promotes the absorption Superior Mesenteric Artery calcium in the intestine and regulates bone mineralization, pharmacological effect and a single dose of calcitriol lasts 3-5 days, the key role of calcitriol in the regulation of calcium metabolism that is stimulating osteoblasts activities skeleton, is a reliable pharmacological basis for its therapeutic effects in osteoporosis. (1 g), from 5 to 6 - Table 2-3. 0.25 mg. (1-1,5 g), from 7 duty 9 years - Table 3-4. Contraindications to the use of drugs: duty and / or hiperkaltsiuriya, duty pregnancy.
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